Well, well. A genetic defect which may explain high LDL/VLDL levels in Europeans (up to 68% of us carry this gene). Carriage of the gene confers a 29% excess risk per allele for coronary artery disease. This news cannot help me now, but offers hope for many folks with (familial) LDL/VLDL hyperlipidaemia in future with the anticipated development of novel agents to target the C/EBP–sortilin 1 pathway.
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